The brain understands the world by building models that predict the future. One of the ways that it does this is by utilizing attractor networks. These small world networks are constantly trying to determine what is a true signal from the constant noise in the neural net. Dr. O'Leary explores how attractor networks have been hypothesized to explain psychosis, depression, and obsessive compulsive disorder, and how our various treatments might work to stabilize these networks.
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Below are references for this episode.
Looijestijn J, Blom JD, Aleman A, Hoek HW, Goekoop R. An integrated network model of psychotic symptoms. Neurosci Biobehav Rev. 2015 Dec;59:238-50. doi: 10.1016/j.neubiorev.2015.09.016. Epub 2015 Sep 30. PMID: 26432501.
Martino M, Magioncalda P. A three-dimensional model of neural activity and phenomenal-behavioral patterns. Mol Psychiatry. 2023 Dec 19. doi: 10.1038/s41380-023-02356-w. Epub ahead of print. PMID: 38114633.
Kuhn T, Haroon J, Spivak NM. A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment. Focus (Am Psychiatr Publ). 2022 Jan;20(1):45-54. doi: 10.1176/appi.focus.20210024. Epub 2022 Jan 25. PMID: 35746937; PMCID: PMC9063598.
Di Domenico D, Mapelli L. Dopaminergic Modulation of Prefrontal Cortex Inhibition. Biomedicines. 2023; 11(5):1276. https://doi.org/10.3390/biomedicines11051276
Gallos, Lazaros K, Hernán A. Makse, and Mariano Sigman. A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks. PNAS. 2012; 109 (8) 2825-2830.
https://doi.org/10.1073/pnas.1106612109
Oldham S, Fornito A. The development of brain network hubs. Dev Cogn Neurosci. 2019 Apr;36:100607. doi: 10.1016/j.dcn.2018.12.005. Epub 2018 Dec 13. PMID: 30579789; PMCID: PMC6969262.
Valdés-Tovar M, Rodríguez-Ramírez AM, Rodríguez-Cárdenas L, Sotelo-Ramírez CE, Camarena B, Sanabrais-Jiménez MA, Solís-Chagoyán H, Argueta J, López-Riquelme GO. Insights into myelin dysfunction in schizophrenia and bipolar disorder. World J Psychiatry 2022; 12(2): 264-285
Valdés-Tovar M, Rodríguez-Ramírez AM, Rodríguez-Cárdenas L, Sotelo-Ramírez CE, Camarena B, Sanabrais-Jiménez MA, Solís-Chagoyán H, Argueta J, López-Riquelme GO. Insights into myelin dysfunction in schizophrenia and bipolar disorder. World J Psychiatry 2022; 12(2): 264-285 [PMID: 35317338 DOI: 10.5498/wjp.v12.i2.264]
Gold PW, Kadriu B. A Major Role for the Lateral Habenula in Depressive Illness: Physiologic and Molecular Mechanisms. Front Psychiatry. 2019 May 22;10:320. doi: 10.3389/fpsyt.2019.00320. PMID: 31231247; PMCID: PMC6558383.
Tura A, Goya-Maldonado R. Brain connectivity in major depressive disorder: a precision component of treatment modalities? Transl Psychiatry. 2023 Jun 9;13(1):196. doi: 10.1038/s41398-023-02499-y. Erratum in: Transl Psychiatry. 2023 Jul 17;13(1):260. PMID: 37296121; PMCID: PMC10256697.
Rolls ET. The orbitofrontal cortex and emotion in health and disease, including depression. Neuropsychologia. 2019 May;128:14-43. doi: 10.1016/j.neuropsychologia.2017.09.021. Epub 2017 Sep 24. PMID: 28951164.
Rolls ET, Loh M, Deco G. An attractor hypothesis of obsessive-compulsive disorder. Eur J Neurosci. 2008 Aug;28(4):782-93. doi: 10.1111/j.1460-9568.2008.06379.x. Epub 2008 Jul 30. PMID: 18671737.
Perneger TV. How to use likelihood ratios to interpret evidence from randomized trials. J Clin Epidemiol. 2021 Aug;136:235-242. doi: 10.1016/j.jclinepi.2021.04.010. Epub 2021 Apr 27. PMID: 33930527.
Avery SN, Rogers BP, McHugo M, Armstrong K, Blackford JU, Vandekar SN, Woodward ND, Heckers S. Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study. Biol Psychiatry Glob Open Sci. 2022 Oct 26;3(4):979-989. doi: 10.1016/j.bpsgos.2022.10.002. PMID: 37881573; PMCID: PMC10593896.
Maller JJ, Welton T, Middione M, Callaghan FM, Rosenfeld JV, Grieve SM. Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI. Sci Rep. 2019 Feb 20;9(1):2418. doi: 10.1038/s41598-018-37905-9. PMID: 30787303; PMCID: PMC6382767.
Kaur A, Basavanagowda DM, Rathod B, Mishra N, Fuad S, Nosher S, Alrashid ZA, Mohan D, Heindl SE. Structural and Functional Alterations of the Temporal lobe in Schizophrenia: A Literature Review. Cureus. 2020 Oct 26;12(10):e11177. doi: 10.7759/cureus.11177. PMID: 33262914; PMCID: PMC7689947.